Get to Know our Staff: Paola Sparagana, Research

Get to Know our Staff: Paola Sparagana, Research

Each year, our team seeks out college students interested in pursuing a career in medicine. Clinical Orthopedic Research Assistants (CORA) are hired at Scottish Rite for Children to assist our experts in performing clinical research tasks and collaborating on research projects. CORA staff are also mentored by our physicians and researchers and given valuable advice and guidance for their future. Each CORA staff member specializes in a specific area of study and works with the staff in that department, receiving a well-rounded experience in their field of interest.
 
What inspired you to apply for the CORA position?
What initially inspired me to apply for a CORA position was the sheer uniqueness of the program. Not only was this an opportunity at a globally distinguished hospital, but it also offered numerous opportunities that seemed essential for my professional growth. The CORA program is tailored toward those who are interested in pursuing advanced degrees in medicine. So, unlike other research assistant positions, CORA offers opportunities that are crucial in creating a competitive applicant for any medical degree program. Such opportunities include designated hours for observing in clinic, developing your own research project and learning from true experts in their field. As someone who had minimal experience with clinical research, this seemed like a terrific opportunity to formally introduce myself to the wonderful world of research!
 
Have you always been interested in medicine and/or research?
I grew up with two parents in the medical field, so it certainly has always felt like a natural topic of interest to me. Despite always having this interest, I wasn’t sure what that meant for me and my future. I never experienced a defining moment where I thought to myself, ‘Yes, medicine is it for me!’ In fact, even up to my senior year of college, I found myself wondering if medicine was just an interest or if this had the potential to be a lifelong career. Fortunately, I found myself at Scottish Rite for Children, where my experiences have gradually transformed interests into ambitions and passions.
 
What is it like working at Scottish Rite for Children?
I certainly have a sense of pride when I come to work. Since its inception, Scottish Rite for Children has maintained a reputation of providing extraordinary patient care and pioneering revolutionary research. The staff and volunteers here are a true testament to the excellence of this organization. Working with children is a humbling experience, but that is a feeling that we all need to learn to embrace. In fact, I often find myself learning valuable lessons from the short interactions I have with the children in clinic. There is so much to learn here, and I am beyond thrilled to be a part of the community!
 
Can you share a few sentences about someone at Scottish Rite who has been a mentor to you and how they have impacted your experience? What project are you working on with that mentor?
While working here, I have had the opportunity to learn from some truly impressive individuals. Within the Rheumatology department, Lynnette Walters has selflessly invested a significant portion of her time into my own professional and personal development. Within a few short months, Lynnette reinforced my abilities to lead with positivity and integrity. I am currently working on an autoimmunity project with Lynnette that consists of obtaining biological samples and examining disease manifestation at the time of sample collection. Julie M. Fuller, M.D., who is mentoring me through a personal project, has also given me direction and confidence since the start of this project.  
 
How do you think this experience will impact your career path?
It has unquestionably already impacted my career path. This experience has solidified my interests in medicine while giving me clinical experience that goes beyond most entry-level positions. I believe this program has solidified the foundation for my professional career while reinforcing my personal development.  
 
What progress have you made toward your career goal since beginning the program?
The CORA program has helped me not only identify my career goal, but it has also helped me set some crucial career development goals. One important aspect of my career development was gaining exposure to other departments and specialties. I have had the opportunity to work with multiple departments such as Rheumatology and Pediatric Developmental Disabilities. Working with different departments has enhanced my workplace flexibility while also allowing me to step outside my job description and create new opportunities for myself. As I have grown more comfortable in my role, I have felt confident in accepting new tasks and projects that had once seemed daunting. Experience has only made me more confident myself!
 
What is your favorite project that you are currently working on or have worked on at Scottish Rite?
My favorite project is probably my own personal project that I am working on with rheumatologist Dr. Fuller. We are working on a case series examining patients with Juvenile Idiopathic Arthritis (JIA) who also present with Temporomandibular Joint involvement. Getting to work through the challenges of research with Dr. Fuller has given me invaluable experience into the fundamentals of the research development. It is incredibly rewarding to watch an idea transform into a project that you can call your own.
 
What advice do you have for future CORA participants?
My first piece of advice would be to embrace the work that is given to you. It is unlikely that you will always know what to do when assigned a new project, but in chaos there is always opportunity! If you use this as an opportunity to learn, then you’re only better preparing yourself for the future. My next piece of advice would be to allow this experience to be more than just professional development. Let this be a time of personal growth for you. Explore your talents, potential, dreams and aspirations. At the end of the day, it is personal growth that gives us the motivation to accomplish meaningful work and advance in our careers. 
 
What is one thing most people don’t know about you?
Prior to this position, my only true research experience was at Texas A&M, where I helped develop open-education resources (OER) for second language education. We developed textbooks that are now used by Introductory Spanish courses at Texas A&M, which provide students with free textbooks! So, despite my minimal experience with clinical research, I believe it was my eagerness to learn fast and prioritize the information needed that has allowed me to excel in this position.
 
Anything else you would like to add?
The CORA positions are a great opportunity at an outstanding institution with world class medical staff and colleagues. I give the program my most heartfelt endorsement!
 
If you are interested in a career in medicine and plan to take a year or two after college before applying to medical school, learn more about becoming a clinical orthopedic research assistant (CORA) on our careers page. Applications for June 2023 positions are being accepted through spring of 2023.
 
If you are in medical school and are interested in a research opportunity, learn more about becoming a medical student research fellow (MSRF) on our careers page.
Researchers At Scottish Rite For Children Awarded Grant From National Institutes Of Health For Clubfoot Genetics Research

Researchers At Scottish Rite For Children Awarded Grant From National Institutes Of Health For Clubfoot Genetics Research

Researchers at Scottish Rite for Children and UT Southwestern Medical Center were recently awarded a grant from the National Institutes of Health (NIH) that will bring new opportunities to discover genetic causes of clubfoot. Clubfoot is a complex foot deformity where one or both feet are turned inward and pointed downward. At Scottish Rite, two nonoperative treatment methods are provided to children with clubfoot, though at times, surgical management may be required.
 
A research team at Scottish Rite, led by Jonathan J. Rios, Ph.D., is investigating the genetic basis of clubfoot. In 2021, Dr. Rios’ team published the largest genetic association study for clubfoot, which included analysis of approximately 8 million genetic markers in more than 8,000 individuals. As part of this effort, his team identified the first gene, FSTL5, associated with clubfoot using this approach. Using similar strategies, Carol Wise, Ph.D., Director of Basic Science Research at Scottish Rite, has led studies discovering genes associated with adolescent idiopathic scoliosis. “This award reflects the expertise of our research staff and the organization’s commitment to research excellence, a combination that enables continued discoveries of the genetic basis for pediatric orthopedic conditions treated at our institution,” Dr. Wise says.

Dr. Rios’ new award will utilize whole-genome sequencing to discover genetic causes of clubfoot. As part of this award, the Gabriella Miller Kid’s First Program will sequence the entire genomes of 407 individuals from 85 families with clubfoot. “The Gabriella Miller Program is a unique opportunity to apply comprehensive genomic technologies to tackle unanswered questions in the field and to discover genetic causes of pediatric orthopedic disorders,” Dr. Rios says. The new Kids First Project on Congenital Clubfoot, led by Dr. Rios, is a collaboration with Dr. Jacqueline Hecht, Associate Dean of Research at the McGovern Medical School at UTHealth Houston.

This is the second Gabriella Miller Project awarded to Dr. Rios. In 2016, the Gabriella Miller Project awarded Drs. Rios and Wise’s study of adolescent idiopathic scoliosis, which included whole-genome sequencing of 598 individuals from 168 families. “Scoliosis and clubfoot are the most frequent orthopedic conditions treated at Scottish Rite,” says Scottish Rite Chief of Staff Daniel J. Sucato, M.D., M.S. “Genetic and basic research is fundamental to improving how we care for children, and ‘big data’ studies such as these allow our scientists to tackle new research questions that will advance our understanding of these conditions.” Learn more about research at Scottish Rite for Children and the Scottish Rite for Children Molecular Genetics research team. Jonathan J. Rios, Ph.D., is the co-director of Molecular Genetics at Scottish Rite, as well as an associate professor in the McDermott Center for Human Growth and Development and the Departments of Orthopaedic Surgery and Pediatrics and is a member of the Simmons Comprehensive Cancer Center at The University of Texas Southwestern Medical Center (UT Southwestern). Carol Wise, Ph.D., is the Director of Basic Research at Scottish Rite and is a professor in the McDermott Center for Human Growth and Development and the Departments of Orthopaedic Surgery and Pediatrics at UT Southwestern. Daniel J. Sucato, M.D., M.S., is the Chief of Staff at Scottish Rite and is a professor in the Department of Orthopaedic Surgery at UT Southwestern.

Adam Jamnik: Medical Student Research Fellow, Research

Adam Jamnik: Medical Student Research Fellow, Research

Scottish Rite for Children offers a Medical Student Research Fellowship (MSRF) for medical students interested in gaining experience in clinical research. Fellows work with a lead faculty mentor throughout the year and several project supervisors who are pediatric orthopedic faculty at Scottish Rite. Fellows work as a crucial part of the research teams in various Centers for Excellence at Scottish Rite and are responsible for a variety of research projects.

Meet Adam, a MSRF at Scottish Rite in 2022 who works with Brandon A. Ramo, M.D., in the Center for Excellence in Spine.

What inspired you to apply for the MSRF position?
I am currently applying to residency in orthopedic surgery and have long felt that I would want to make research a part of my future career. Though I have had the opportunity to conduct research in medical school and as an undergraduate, I knew that a year-long research fellowship position would dramatically enhance my research skills, ultimately benefiting me for years to come. The MSRF position was a perfect fit for me. I am primarily interested in pediatric orthopedics, so Scottish Rite for Children, as a preeminent clinical and research facility, was always on my radar. I knew that the amazing physicians and research infrastructure here would provide me the support and learning opportunities to make the most of this year.

Have you always been interested in medicine and/or research?
I primarily became interested in medicine during high school, where I loved my science classes. During that time, I was also a ski instructor for children ages 3-7. That experience made me realize that I would really enjoy a job working with people and helping others.

When I was thinking of ways I could combine my passions for science and making a direct impact on peoples’ lives, medicine seemed like a natural fit. As for my interest in research, that began during college. The laboratory components for my biology and chemistry classes were great learning experiences, but I wanted the experiments I was conducting to further our understanding of the world around us and to have the experience of formulating my own questions. I ended up getting involved in two research labs — one that studied epigenetics and another that studied the interaction between hunger and sleep.

What is it like working at Scottish Rite for Children?
Working at Scottish Rite has far surpassed my expectations. First, I think the organization in general has an incredibly positive atmosphere. The people seem genuinely happy to come to work and are excited to help children dealing with orthopedic conditions. The attendings have given me invaluable career guidance and research mentorship. The research coordinators have been instrumental in supporting my projects and making sure I can make the most of my year here.

Can you share a few sentences about someone at Scottish Rite who has been a mentor to you and how they have impacted your experience? What project are you working on with that mentor?
One of my primary mentors at Scottish Rite is Dr. Brandon Ramo. From the outset, Dr. Ramo has supported me through every step of the research process. One of the projects we are working on is determining how adolescents’ experience with scoliosis has changed over the past two decades. During that time, Scottish Rite has given a survey (known as the SRS-30) to patients prior to their surgery to gauge their level of pain, how they feel about their appearance, activity levels and mental health. We determined that some of these metrics have taken a turn for the worse and hypothesize this may be related to changing societal pressures and norms.

How do you think this experience will impact your career path?
As I mentioned, I am hoping to make research a part of my future career. My experience at Scottish Rite has allowed me to further develop an understanding of the research process as well as the skills needed to conduct research, such as developing good research questions, selecting appropriate inclusion and exclusion criteria, identifying the variables needed to answer a given research question and ultimately publishing results. I am confident that this experience will improve the quality of the research that I conduct throughout my career and will likely influence the practice setting I ultimately select for my career.

What progress have you made towards your career goal since beginning the program?
I am applying for residency this year, and interview season just started at the beginning of December! My research experience at Scottish Rite will likely be brought up in all my interviews, so I am grateful that the team here has helped me have such a productive time thus far.

What is your favorite project that you are currently working on or have worked on at Scottish Rite?
My favorite project has been the one I mentioned earlier, on the evolution of SRS scores. Another project that I am proud of looks at the performance of magnetically controlled growing rods (MCGR), which is a newer scoliosis treatment for patients that are still growing. It involved reviewing hundreds of X-rays, but I am really happy with the end product and think it adds significantly to the conversation on a newer treatment modality.

What advice do you have for future MSRF participants?
My advice would be to really dive in! A year is a short period of time, especially in research when there are so many moving parts. Don’t be afraid to juggle a few projects at once because each project will demand different amounts of attention at different times.

What is one thing most people don’t know about you?
I love trying different restaurants! I am originally from New York, so it has been great exploring the Dallas food-scene.

Anything else you would like to add?
I would just like to reiterate my thanks to Scottish Rite! I am so grateful for all the resources they’ve provided me. The work that is done here for patients is absolutely incredible, and it is very rewarding to have played a small part in that. This one year will benefit me and my career for decades to come. I am confident that through those years, I will leverage this experience for the benefit of my patients.

We’re recruiting Medical Student Research Fellows for 2023! If you are a third-year medical student looking to take a gap year before applying to residency, take advantage of this unique opportunity! Only three positions are available for 2023.

Learn more and apply here on our Careers page.

Inaugural Pediatric Musculoskeletal Ultrasound Conference Was a Success!

Inaugural Pediatric Musculoskeletal Ultrasound Conference Was a Success!

The results are in, and the Pediatric Musculoskeletal Ultrasound (PMSKUS) Fundamentals Course met and exceeded expectations on several fronts. We’re getting busy planning the next opportunity to participate in the spring of 2023. Join the wait list today.
We hosted 28 attendees from across the country, including two former Scottish Rite for Children fellows (orthopedics and rheumatology). Participants left telling us they were likely or very likely to recommend this conference to colleagues. Attendees represented a wide variety of professions and specialties including physicians in family medicine, sports medicine, rheumatology and radiology as well as an athletic trainer, physical therapist and sonographer.

“Scottish Rite is not only defining but also introducing the use of MSK US in this population to providers across the country. This conference was exceptional from the planning to the delivery, to having live pediatric models. There are no other ultrasound conferences focused on pediatrics.”

—    Guest Faculty – Jon A. Jacobson, M.D.

The guest faculty Jon A. Jacobson, M.D., is a board-certified diagnostic MSK radiologist at Lenox Hill Radiology in New York City, New York. He completed a Bachelor of Science in Biological Science at Wayne State University and his medical degree (MD) at the Wayne State University School of Medicine. He completed a diagnostic radiology residency at Henry Ford Hospital and a MSK radiology fellowship at the University of California San Diego (UCSD). He has served as section chief of Musculoskeletal Radiology at the University of Michigan and the University of Cincinnati.

Unlike any other program offered today, this pediatric-focused program offered didactic lectures alternating with hands-on sessions. In the scanning sessions, pediatric models, ranging from ages 5 to 15, gave attendees the opportunity to practice scanning normal anatomy as well as several patients with active juvenile idiopathic arthritis. The procedural scanning session employed tofu, olives and ham to offer practice for performing ultrasound-guided injections.

We Asked Attendees: What do you consider to be the best part of the program?

“The program is very organized, the hands-on sessions being throughout the day is a great idea.”

“Ample hands-on practice with different faculty, pediatric US models with specific pathology findings.”

“Good flow between lecture and hands-on, good amount of time spent in each. Kept basic but flexible to the level of the learner.”

“Hands-on experience with awesome mentors. Love the combo of lecture to US to lecture to US to break up the day.”

“Thank you! Stellar Faculty!”

“Hands-on focused course with small groups was great.”

“Hands-on seeing actual pathology and practicing hands-on injections.”

Image at Top: Course directors (in bold) and faculty of the inaugural PMSKUS conference at Scottish Rite for Children’s Frisco, Texas, campus. From L to R: Vivek Kalia, M.D., M.P.H., M.S., Jon A. Jacobson, M.D., Yassine Kanaan, M.D, Matthew Hammer, M.D., Heather Benham, D.N.P., APRN, CPNP-PC, Jacob C. Jones, M.D., RMSK, Joseph Chang, M.D., Mark Bowens, RDMS, Kelley Sherrard, RDMS

NBC DFW: Scottish Rite, UTSW Awarded $6.6 Million for Scoliosis Research

NBC DFW: Scottish Rite, UTSW Awarded $6.6 Million for Scoliosis Research

Researchers at Scottish Rite for Children and UT Southwestern were awarded $6.6 million over five years by the National Institutes of Health (NIH) to continue research into the underlying causes of idiopathic scoliosis.

The grant which was announced by Scottish Rite Tuesday will fund a multisite program titled “Developmental Mechanisms of Idiopathic Scoliosis.” The goal of the program is to understand the biological causes of idiopathic scoliosis to develop future treatments.

Read the entire article.

Scottish Rite for Children Awarded Department of Defense Research Grant

Scottish Rite for Children Awarded Department of Defense Research Grant

Researchers at Scottish Rite for Children were awarded a $100,000 grant from the Department of Defense’s Neurofibromatosis Research Program. This grant will fund efforts to investigate new treatments for bone fractures in children with Neurofibromatosis Type 1 (NF1).
 
NF1 is an uncommon genetic disorder associated with pediatric and adult tumors. Some children with NF1 develop orthopedic conditions requiring treatment, such as scoliosis and persistent bone fractures. For many years, Scottish Rite has been recognized as an international leader in the care of children with NF1. Recently researchers at Scottish Rite, led by former Assistant Chief of Staff B. Stephens Richards, M.D., co-led a clinical trial testing the INFUSE graft to treat persistent fractures in children with NF1. Surgery is currently the best option for children with NF1, but a team of Scottish Rite researchers is dedicated to developing new, less invasive treatment methods.
 
“Our team has dedicated years of research to understand why these persistent fractures occur in children with NF1,” says Jonathan Rios, Ph.D., assistant director of Molecular Genetics and lead investigator of the study. While several drugs are either approved by the FDA or currently in clinical trials to treat tumor manifestations of NF1, no such treatments exist for orthopedic conditions associated with NF1. “All of our team’s efforts have led to this moment, where we can now test new therapies in the lab. And by evaluating therapies already in clinical trials for other aspects of NF1, we hope to rapidly translate the most promising of these therapies to treat fractures in children with NF1,” Rios says.
 
“Dr. Rios’ research will allow us to advance how we care for children with NF1 suffering from persistent fractures and will improve the lives of children with NF1 at Scottish Rite and around the world,” Chief of Staff for Scottish Rite for Children Daniel J. Sucato, M.D., M.S., says. “Dr. Rios’ research exemplifies Scottish Rite’s reputation as an international leader in translational research that will bring new treatments to children for years to come,” Director of Basic Research Carol Wise says.
 
search about our leading-edge research.
 
Jonathan J. Rios, Ph.D., is the assistant director of Molecular Genetics at Scottish Rite, as well as an associate professor in the McDermott Center for Human Growth and Development and the Departments of Orthopaedic Surgery and Pediatrics and is a member of the Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center (UTSW). Carol Wise, Ph.D., is the Director of Basic Research at Scottish Rite and is a professor in the McDermott Center for Human Growth and Development and the Departments of Orthopaedic Surgery and Pediatrics at UTSW. Dr. Sucato is the Chief of Staff at Scottish Rite and is a Professor in the Department of Orthopaedic Surgery at UTSW.